Is Oncolytic Virotherapy a permanent cure for malignant gliomas?

Abstract

Of all malignant glioma forms, glioblastoma is the most frequently present form. The treatment of this highly aggressive tumor form by applying conventional therapies is of low success, leading to a low survival rate. As representatives of immunotherapeutic agents, oncolytic viruses contribute to the revolution in cancer therapy. Although promising, the efficiency of oncolytic viruses for treating glioblastoma is also limited. This is a reason why further optimization of oncolytic virotherapy is necessary. In this work, we review some of glioblastoma's specificities and provide information about the current status of oncolytic virotherapy.